GARP antibody, Cyclic nucleotide-gated cation channel beta-1 antibody, CNGB1 antibody, CNG channel beta-1 antibody, CNG-4 antibody, CNG4 antibody

Rabbit antibody to GARP

$240USD

Code	OSC00174W
ID Tag	Rb1048-020809-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from the n-terminal region of human CNG channel beta-1 (GARP, Glutamic acid-rich protein) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate	Unconjugated antibody
Accession	CNGB1_HUMAN CNGB1_RAT CNGB1_MOUSE
Also known as	CNGB1, Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated channel beta-1, Cyclic nucleotide-gated cation channel 4, CNG channel 4, CNG-4, CNG4, Cyclic nucleotide-gated cation channel modulatory subunit, Glutamic acid-rich protein, GARP, Cyclic nucleotide-gated cation channel gamma, CNCG2, CNCG3L, CNCG4, RCNC2
Target	FUNCTION: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor "dark noise" and allowing these sensory cells to operate at the single photon detection limit. Subcellular location: Membrane; Multi-pass membrane protein Involvement in disease: Defects in CNGB1 are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for GARP.
Spcs X-react.	Mouse, rat, human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Chen T.-Y, et al. Nature 362:764-767(1993) 2. Ardell M.D, et al. Genomics 28:32-38(1995) 3. Ardell M.D, et al. FEBS Lett. 389:213-218(1996) 4. Grunwald M.E, et al. J. Biol. Chem. 273:9148-9157(1998) 5. Pentia D.C, et al. J. Biol. Chem. 281:5500-5505(2006)
Limitation	For research use only

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