A synthetic peptide from rat Olfactory Marker Protein (OMP) conjugated to immunogenic carrier protein has been used as the antigen. The peptide is homologous with the corresponding sequence derived from OMP protein in mouse.
Also known as
Olfactory neuronal-specific protein
Olfactory marker protein (OMP) is an abundant, 19-kDa, cytosolic protein that is almost exclusively expressed in mature, functioning, olfactory neurons but not in the neural precursor basal cells. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Its tissue-specific expression in the receptor cells together with the results of the mouse knockout studies show that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. FUNCTION: May act as a modulator of the olfactory signal-transduction cascade. SUBUNIT: Interacts with BEX1 and BEX2. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Uniquely associated with mature olfactory receptor neurons. SIMILARITY: Belongs to the olfactory marker protein family.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Margolis, F. L. Scand J Immunol Suppl. 9: 181-99 (1982)
2. Moriya-Ito et al. Chem. Senses 30 (2), 111-119 (2005)
3. Baldisseri et al. J. Mol. Biol. 319 (3), 823-837 (2002)
4. Rogers et al. Proc. Natl. Acad. Sci. U.S.A. 84 (6), 1704-1708 (1987)
5. Grillo, M. et al. Int J Dev Neurosci. 14 (7-8), 813-22 (1996)
6. Margolis, J. W. et al. J Biomol NMR. 33 (1), 63-8 (2005)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user. For IHC, Zamboni' s or 4% PFA fixatives are recommended.
Highly specific for mature olfactory neurons (including axon and terminals).
Rat, mouse. Other species have not yet been tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.