Rb417-200308-WS

A synthetic peptide from n-terminal region of mouse Brain-expressed X-linked protein 1 and 2 (BEX1, BEX2) conjugated to an immunogenic carrier protein was used as the antigen.

BEX1_RAT
BEX2_RAT
BEX1_MOUSE
BEX2_MOUSE

Brain expressed gene 1, BEX1, EG2RVC; BEX2, Brain-expressed X-linked protein 2 homolog

BEX1:
FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
SUBUNIT: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
TISSUE SPECIFICITY: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.
DEVELOPMENTAL STAGE: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level).
BEX2:
SUBUNIT: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.

Polyclonal, whole serum

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Feng Y, et al. Gene 329:93-101(2004).
2. Alvarez E, et al. Gene 357:18-28(2005).
3. Vilar M, et al. EMBO J. 25:1219-1230(2006).

For research use only

	Code Product Name OSB00005W Rabbit antibody to BEX1

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for BEX1 and BEX2.

Rat, mouse. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

This item will be shipped to you at ambient temperature in a lyophilised form.