A synthetic peptide from the internal region of rat HOMER3 (Home3, Vesl-3, Vesl3, Homer-3) conjugated to an immunogenic carrier protein was used as the antigen.
Also known as
Home3, Homer protein homolog 3, VASP/Ena-related gene up-regulated during seizure and LTP 3, Vesl-3, Vesl3
FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release.
SUBUNIT: Encodes coiled-coil structures that mediate homo- and heteromultimerization.
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells.
It may interact with group I metabotropic glutamate receptors and regulate their coupling to membrane ion channels.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Kammermeier, P. J, et al. J. Neurosci. 20 (19), 7238-7245(2000).
2. Xiao, B, et al. Neuron 21 (4), 707-716(1998).
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specific for Homer3.
Rat, mouse. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.