HOMER1 antibody, Home 1 antibody, Home1 antibody, SYN47 antibody

Rabbit antibody to internal region of HOMER1 (Home1, SYN47): whole serum

$240USD

Code	OSH00001W
ID Tag	Rb637-170808-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from the internal region of human HOMER1 (Home1, Homer protein homolog 1, SYN47) conjugated to an immunogenic carrier protein was used as the antigen. The immunogen is homologous in mouse, rat, monkey and xenopus.
Conjugate	Unconjugated antibody
Accession	HOME1_HUMAN HOME1_MOUSE HOME1_RAT HOME1_MONKEY
Also known as	Home1, Homer protein homolog 1, SYN47
Background	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with CENTG1. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for Homer1.
Spcs X-react.	Mouse, rat, human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Xiao B, et al. Neuron 21:707-716(1998). 2. Roche K.W, et al. J. Biol. Chem. 274:25953-25957(1999). 3. Xiao B, et al. Curr. Opin. Neurobiol. 10:370-374(2000). 4. Saito H, et al. Biochem. Biophys. Res. Commun. 296:523-523(2002). 5. Tu J.C, et al. Neuron 21:717-726(1998). 6. Salanova M, et al. Cell Calcium 32:193-200(2002). 7. Sakamoto K, et al. Biochem. Biophys. Res. Commun. 352:1-5(2007). 8. Brakeman P.R, et al. Nature 386:284-288(1997). 9. Kato A, et al. FEBS Lett. 412:183-189(1997). 10. Irie K, et al. J. Mol. Biol. 318:1117-1126(2002).
Limitation	For research use only

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OSH00024W	Goat antibody to n-terminal region of HOMER1 (Home1, SYN47): whole serum