GW182 antibody, cytoplasm marker antibody, TNRC6 antibody, TNRC6A antibody, Protein GW1 antibody, Sjoegren syndrome, autoimmune

Rabbit antibody to internal region of GW182 autoantigen (TNRC6A): whole serum

$240USD

Code	OSG00047W
ID Tag	Rb1021-280609-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from the internal region of human GW182 autoantigen (TNRC6A) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate	Unconjugated antibody
Accession	GW182_HUMAN GW182_RAT GW182_MOUSE
Also known as	Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, Glycine-tryptophan protein of 182 kDa, Protein GW1, TNRC6A, TNRC6, CAGH26, TNR6A
Background	Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Subcellular location: Cytoplasm › P-body. Note: Mammalian P-bodies are also known as GW bodies (GWBs). Tissue specificity: Ubiquitous. Involvement in disease: Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for GW182.
Spcs X-react.	Human, rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Eystathioy T, et al. Mol. Biol. Cell 13:1338-1351(2002) 2. Bechtel S, et al. BMC Genomics 8:399-399(2007) 3. Nagase T, et al. DNA Res. 7:143-150(2000) 4. Eystathioy T, et al. J. Mol. Med. 81:811-818(2003) 5. Lian S.L, et al. RNA 15:804-813(2009)
Limitation	For research use only

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