Rabbit antibody to human Syntaxin-16 (Syntaxin 16, STX16, Syn16): whole serum

$240USD

Code	OSS00031W
ID Tag	Rb330-1h-200308-WS
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Unit size	100 µl
Immunogen	A synthetic peptide as a part of human Syntaxin-16 (Syntaxin 16, STX16, Syn16) conjugated to an immunogenic carrier protein was used as the immunogen.
Conjugate	Unconjugated antibody
Accession	STX16_HUMAN
Also known as	Syntaxin 16, STX16, Syn16
Background	FUNCTION: SNARE involved in a vesicular transport step within the Golgi stack. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein. SUBCELLULAR LOCATION: Isoform C: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous. DISEASE: Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B) Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Specificity	Appears to be specific for Syntaxin-16.
Spcs X-react.	Human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Simonsen A, et al. Eur. J. Cell Biol. 75:223-231(1998). 2. Tang B.L, et al. Biochem. Biophys. Res. Commun. 242:673-679(1998). 3. Deloukas P, et al. Nature 414:865-871(2001). 4. Bastepe M, et al. J. Clin. Invest. 112:1255-1263(2003). 5. Linglart A, et al. Am. J. Hum. Genet. 76:804-814(2005).
Limitation	For research use only

PDF Data Sheet	- Click to download the Data Sheet
MSDS	- Click to download the Material Safety Data Sheet

Associated Products

Code	Product Name
OSS00014W	Rabbit antibody to mouse, chicken, orangutan, pig Syntaxin-16 (Syntaxin 16, STX16, Syn16): whole serum