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Code
OSR00106W
$240USD
ID Tag
Rb144-281007-WS
Immunogen
A synthetic peptide from the 4th cytoplasmic loop of human Mas-related G-protein coupled receptor member D (MRGPRD) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known as
Mas-related G-protein coupled receptor, member D; Beta-alanine receptor, G-protein coupled receptor TGR7, MRGD
Target
FUNCTION: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Isotype
Polyclonal, whole serum
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Transportation
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Zylka M.J, et al. Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
2. Shinohara T, et al. J. Biol. Chem. 279:23559-23564(2004).
3. Takeda S, et al. FEBS Lett. 520:97-101(2002).
4. Dong,X, et al. ell 106 (5), 619-632 (2001).
2. Shinohara T, et al. J. Biol. Chem. 279:23559-23564(2004).
3. Takeda S, et al. FEBS Lett. 520:97-101(2002).
4. Dong,X, et al. ell 106 (5), 619-632 (2001).
Limitation
For research use only
Code
OSR00106W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for MRGPRD.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Transportation
This item will be shipped to you at ambient temperature in a lyophilised form.
Code
OSR00106W
$240USD
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Code
OSR00106W
$240USD
This item is in our stock. The expected delivery time is within 5 business days worldwide.
Products
Rabbit antibody to MRGPRD
