Rabbit antibody to human, mouse & rat RSSA (RPSA) precursor (alternative 1): whole serum

$240USD

Code	OSR00145W
ID Tag	Rb235-251107-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide as a part of human, mouse and rat RSSA conjugated to immunogenic carrier protein was used as the immunogen.
Conjugate	Unconjugated antibody
Accession	RSSA_HUMAN RSSA_MOUSE RSSA_RAT
Also known as	Immature laminin receptor, nonintegrin laminin receptor precursor, 40S ribosomal protein SA, p40, 34/67 kDa laminin receptor, Colon carcinoma laminin-binding protein, NEM/1CHD4, Multidrug resistance-associated protein MGr1-Ag, LAMBR, LAMR1, RPSA ribosomal protein SA, LRP, 67LR, 37LRP
Background	The expression of nonintegrin laminin receptor precursor protein on olfactory stem and progenitor cells has been reported by Schwob J, et al ( See ref. 6). Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Specificity	Specific for RSSA precursor expressed on globose basal cells (GBCs).
Spcs X-react.	Rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Yow H, et al. Proc. Natl. Acad. Sci. U.S.A. 85:6394-6398(1988). 2. Van den Ouweland A.M.W, et al. Nucleic Acids Res. 17:3829-3843(1989). 3. Jackers P, et al. Oncogene 13:495-503(1996). 4. Satoh K, et al. Cancer Lett. 62:199-203(1992). 5. Kenmochi N, et al. Genome Res. 8:509-523(1998). 6. Woochan J, et al. J. Comp. Neurol. 502:367–381 (2007).
Limitation	For research use only

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