Cytoplasmic domain p75 antibody, cytoplasmic domain p75NTR antibody

Rabbit antibody to extracellular domain of p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR): whole serum

$240USD

Code	OSP00048W
ID Tag	Rb878-290309-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from the extracellular domain of human p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in many other species including mouse and rat.
Conjugate	Unconjugated antibody
Accession	p75NTR_HUMAN p75NTR_RAT p75NTR_MOUSE
Also known as	Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR
Background	FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for p75NTR.
Spcs X-react.	Human, rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Johnson D, et al. Cell 47:545-554(1986) 2. Ye X, et al. J. Biol. Chem. 274:30202-30208(1999) 3. Khursigara G, et al. J. Biol. Chem. 274:2597-2600(1999) 4. Irie S, et al. FEBS Lett. 460:191-198(1999) 5. Wooten M.W, et al. J. Biol. Chem. 276:7709-7712(2001) 6. Mi S, et al. Nat. Neurosci. 7:221-228(2004) 7. Chapman B.S, et al. J. Neurochem. 66:1707-1716(1996)
Limitation	For research use only

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MSDS	- Click to download the Material Safety Data Sheet

Associated Products

Code	Product Name
OSP00058G	Rabbit antibody to extracellular domain of p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR): IgG