Rabbit antibody to extracellular domain of human TrkA (High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A): IgG

$240USD

Code	OST00122G
ID Tag	Rb447-150608-G
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Unit size	500 µg
Immunogen	A synthetic peptide from the extracellular domain of human TrkA (High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A) conjugated to an immunogenic carrier protein was used as the immunogen.
Conjugate	Unconjugated antibody
Accession	TRKA_HUMAN
Also known as	High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A, Neurotrophic tyrosine kinase receptor type 1, Slow nerve growth factor receptor
Background	FUNCTION: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and ARMS. Can form a ternary complex with NGFR and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note: Endocytosed to the endosomes upon treatment of cells with NGF. TISSUE SPECIFICITY: Isoform Trka-II is primarily expressed in neuronal cells; isoform Trka-I is found in non-neuronal tissues.
Host	NZ white rabbit
Purity	IgG
Clonality	Polyclonal
Isotype	Polyclonal, IgG
Applications	IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.
Specificity	Specific for TrkA.
Spcs X-react.	Human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Martin-Zanca D, et al. Mol. Cell. Biol. 9:24-33(1989). 2. Shelton D.L, et al. J. Neurosci. 15:477-491(1995). 3. Indo Y, et al. Jpn. J. Hum. Genet. 42:343-351(1997). 4. Gregory S.G, et al. Nature 441:315-321(2006). 5. Fujimoto M, et al. Oncogene 24:5108-5118(2005). 6. Martin-Zanca D, et al. Nature 319:743-748(1986). 7. Hempstead B.L, et al. Nature 350:678-683(1991). 8. Klein R, et al. Cell 65:189-197(1991). 9. Loeb D.M, et al. J. Biol. Chem. 269:8901-8910(1994). 10. Stephens R.M, et al. Neuron 12:691-705(1994).
Limitation	For research use only

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Associated Products

Code	Product Name
OST00121W	Rabbit antibody to extracellular domain of human TrkA (High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A): whole serum