GRIK2 antibody, GLUR6 antibody, EAA4 antibody, Excitatory amino acid receptor 4 antibody

Rabbit antibody to 1t extracellular domain of GRIK2 (GLUR6, Glutamate receptor 6): whole serum

$240USD

Code	OSG00059W
ID Tag	Rb1175-260909-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from 1t extracellular domain of mouse GRIK2 (GLUR6, Glutamate receptor 6) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate	Unconjugated antibody
Accession	GLUR6_MOUSE GLUR6_HUMAN GLUR6_RAT
Also known as	Glutamate receptor, ionotropic kainate 2, Glutamate receptor 6, GluR-6, GluR6, Excitatory amino acid receptor 4, EAA4, Glutamate receptor beta-2
Background	FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of autosomal recessive mental retardation type 6 (MRT6). Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Tissue specificity: Expression is higher in cerebellum than in cerebral cortex.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for GRIK2.
Spcs X-react.	Mouse, rat, human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Gregor P, et al. NeuroReport 4:1343-1346(1993) 2. Morita T, et al. Brain Res. Mol. Brain Res. 14:143-146(1992) 3. Koehler M, et al. Neuron 10:491-500(1993) 4. Zhang W, et al. Neuron 61:385-396(2009) 5. Herb A, et al. Proc. Natl. Acad. Sci. U.S.A. 93:1875-1880(1996)
Limitation	For research use only

IHC on rat spinal cord (paraffin section) using Rabbit antibody to 1t extracellular domain of GRIK2 (GLUR6, Glutamate receptor 6): whole serum (OSG00059W) at 1 : 200 dilution, incubated overnight at 4C, developed with DAB/Ni and counterstained with hematoxylin.

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