Rabbit antibody to 1t cytoplasmic loop of human TRPV2 (VRL, VRL1, VRL-1, OTRPC2): whole serum

$240USD

Code	OST00211W
ID Tag	Rb646-240808-WS
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Unit size	100 µl
Immunogen	A synthetic peptide from the 1t cytoplasmic loop of human TRPV2 (VRL, VRL1, VRL-1, OTRPC2) conjugated to an immunogenic carrier protein was used as the immunogen. The location of the epitope is highlighted in green.
Conjugate	Unconjugated antibody
Accession	TRPV2_HUMAN
Also known as	Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein, VRL, VRL1, VRL-1, OTRPC2, MGC12549
Background	This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. SUBUNIT: Homotetramer. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Specificity	Appears to be specific for TRPV3.
Spcs X-react.	Human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Caterina M.J, et al. Nature 398:436-441(1999). 2. Saunders C.I, et al. Mol. Immunol. 44 (6), 1429-1435 (2007). 3. Chi A, et al. J. Proteome Res. 5 (11), 3135-3144 (2006). 4. McCleverty C.J, et al. Protein Sci. 15 (9), 2201-2206 (2006). 5. Penna A, et al. Cell Calcium 39 (6), 495-507 (2006). 6. Clapham D.E, et al. Pharmacol. Rev. 57 (4), 427-450 (2005). 7. Voets T, et al. J. Biol. Chem. 277 (37), 33704-33710 (2002). 8. Tominaga M, et al. Jpn. J. Pharmacol. 83 (1), 20-24 (2000). 9. Caterina M.J, et al. Nature 398 (6726), 436-441 (1999). 10. Smith G.D, et al. Nature 418 (6894), 186-190 (2002).
Limitation	For research use only

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