| Code |
OST00225G |
| ID Tag |
Rb658-060908-G |
| Ordering info |
Order online using the shopping cart ("Add to Cooler"), by email to
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or fax to 61-8-827 0 8586 and pay via PayPal by
MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors.
This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
 |
| Unit size |
500 µg |
| Immunogen |
A synthetic peptide from the cytoplasmic domain of TrkB (BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase, Trk-B) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse. |
| Conjugate |
Unconjugated antibody |
| Accession |
TRKB_HUMAN
TRKB_RAT
TRKB_MOUSE |
| Also known as |
Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor |
| Background |
FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Host |
NZ white rabbit |
| Purity |
IgG |
| Clonality |
Polyclonal |
| Isotype |
Polyclonal, IgG |
| Applications |
IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. |
| Specificity |
Specific for TrkB. |
| Spcs X-react. |
Human, rat, mouse. Other species not yet tested. |
| Format |
Lyophilised |
| Reconstitution |
Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage |
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Expiry Date |
12 months after reconstitution |
| Transportation |
This item will be shipped to you at ambient temperature in a lyophilised form. |
| References |
1. Klein R, et al. EMBO J. 8:3701-3709(1989).
2. Klein R, et al. Cell 61:647-656(1990).
3. Carninci P, et al. cience 309:1559-1563(2005).
4. Ninkina N, et al. J. Biol. Chem. 272:13019-13025(1997).
5. Soppet D, et al. Cell 65:895-903(1991).
6. Ballif B.A, et al. J. Proteome Res. 7:311-318(2008). |
| Limitation |
For research use only |
Primary Antibodies 
