P2Y5 antibody, P2RY5 antibody, Purinergic receptor 5 antibody, P2Y purinoceptor 5 antibody

Rabbit antibody to a cytoplasmic domain of P2Y5 (P2RY5): whole serum

$240USD

Code	OSP00063W
ID Tag	Rb958-280609-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from the a cytoplasmic domain of human P2Y5 (P2RY5) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate	Unconjugated antibody
Accession	P2RY5_HUMAN P2RY5_RAT P2RY5_MOUSE
Also known as	P2Y purinoceptor 5, P2RY5, Purinergic receptor 5, ATP receptor, Oleoyl-L-alpha-lysophosphatidic acid receptor, RB intron encoded G-protein coupled receptor
Background	FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Defects in P2RY5 are a cause of autosomal recessive woolly hair (ARWH). Woolly hair refers to a phenotypic variant with fine and tightly curled hair. Defects in P2RY5 are the cause of localized autosomal recessive hypotrichosis type 3 (LAH3). LAH3 is a form of hereditary isolated alopecia characterized by diffuse and progressive hair loss, usually beginning in early childhood. Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes. Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway. Subcellular location: Membrane; Multi-pass membrane protein.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for P2RY5.
Spcs X-react.	Human, rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Toguchida J, et al. Genomics 17:535-543(1993) 2. Herzog H, et al. Genome Res. 6:858-861(1996) 3. Ota T, et al. Nat. Genet. 36:40-45(2004) 4. Dunham A, et al. Nature 428:522-528(2004) 5.Pasternack S.M, et al. Nat. Genet. 40:329-334(2008)
Limitation	For research use only

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