A synthetic peptide from the cytoplasmic domain of human KCNE3 (Potassium voltage-gated channel subfamily E member 3) conjugated to an immunogenic carrier protein was used as the antigen.
Also known as
Potassium voltage-gated channel subfamily E member 3, Minimum potassium ion channel-related peptide 2, Potassium channel subunit beta MiRP2, MinK-related peptide 2
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion.
Tissue specificity: Widely expressed with highest levels in kidney and moderate levels in small intestine.
Subcellular location: Membrane; Single-pass type I membrane protein.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Melman Y.F, et al. J. Biol. Chem. 276:6439-6444(2001)
2. Schroeder B.C, et al. Nature 403:196-199(2000)
3. Abbott G.W, et al. Cell 104:217-231(2001)
4. Dias Da Silva M.R, et al. J. Clin. Endocrinol. Metab. 87:4881-4884(2002)
5. Ohno S, et al. Hum. Mutat. 30:557-563(2009)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for KCNE3.
Human, rat, mouse. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.