Sortilin antibody, Neurotensin receptor 3 antibody, NTR3 antibody, Sort1 antibody

Rabbit antibody to cytoplasmic domain of human Sortilin (Neurotensin receptor 3, NTR3, Sort1): whole serum

$240USD

Code	OSS00082W
ID Tag	Rb643-170808-WS
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Unit size	100 µl
Immunogen	A synthetic peptide from the cytoplasmic domain of human Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to an immunogenic carrier protein was used as the immunogen.
Conjugate	Unconjugated antibody
Accession	SORT_HUMAN
Also known as	Neurotensin receptor 3, NTR3, NT3, Glycoprotein 95, Gp95, 100 kDa NT receptor
Background	FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. SUBUNIT: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. TISSUE SPECIFICITY: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for Sortilin.
Spcs X-react.	Human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Petersen C.M, et al. J. Biol. Chem. 272:3599-3605(1997). 2. Gregory S.G, et al. Nature 441:315-321(2006). 3. Mazella J, et al. J. Biol. Chem. 273:26273-26276(1998). 4. Nielsen M.S, et al. J. Biol. Chem. 274:8832-8836(1999). 5. Nielsen M.S, et al. EMBO J. 20:2180-2190(2001). 6. Maeda S, et al. J. Cell. Physiol. 193:73-79(2002). 7. Shiba T, et al. Nature 415:937-941(2002). 8. Martin S, et al. J. Neurosci. 23:1198-1205(2003). 9. Teng H.K, et al. J. Neurosci. 25:5455-5463(2005). 10. Zahedi R.P, et al. J. Proteome Res. 7:526-534(2008).
Limitation	For research use only

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Associated Products

Code	Product Name
OSS00144G	Rabbit antibody to cytoplasmic domain of human Sortilin (Neurotensin receptor 3, NTR3, Sort1): IgG