Cav3.3 antibody, CACNA1I antibody

Rabbit antibody to CACNA1I

$240USD

Code	OSC00089W
ID Tag	Rb809-140209-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide from a cytoplasmic domain of human CACNA1I (Cav3.3) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Conjugate	Unconjugated antibody
Accession	CACNA1I_HUMAN CACNA1I_RAT CACNA1I_MOUSE
Also known as	Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3
Target	Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Brain specific
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Specificity	Specific for CACNA1I.
Spcs X-react.	Human, rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Mittman S, et al. Neurosci. Lett. 269:121-124(1999) 2. Monteil A, et al J. Biol. Chem. 275:16530-16535(2000) 3. Gomora J.C, et al. Biophys. J. 83:229-241(2002) 4. Dunham I, et al. ature 402:489-495(1999) 5. Zhang D, et al. J. Biol. Chem. 281:22332-22341(2006)
Limitation	For research use only

IHC on rat brain (paraffin section) using Rabbit antibody to CACNA1I (OSC00089W) at 1 : 500 dilution incubated overnight at 4C. Nerve fibers are intensely stained.

IHC on rat brain (paraffin section) using Rabbit antibody to CACNA1I (OSC00089W) at 1 : 500 dilution incubated overnight at 4C.

IHC on rat spinal cord (free floating sections) using Rabbit antibody to CACNA1I (OSC00089W) at 1 : 300 dilution incubated overnight at 4C and developed with DAB/Ni.

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Associated Products

Code	Product Name
OSC00115G	Rabbit antibody to a cytoplasmic domain of CACNA1I (Cav3.3): IgG