| Code |
OSR00134W |
| ID Tag |
Rb130-281007-WS |
| Ordering info |
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This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
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| Unit size |
100 µl |
| Immunogen |
A synthetic peptide from c-terminal region of human transient receptor potential cation channel subfamily M member 4 (TRPM4, melastatin-4) conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate |
Unconjugated antibody |
| Accession |
TRPM4_HUMAN |
| Also known as |
Transient receptor potential cation channel subfamily M member 4, long transient receptor potential channel 4, hTRPM4, melastatin-4, calcium-activated non-selective cation channel 1, TRPM4, TRPM4B, FLJ20041 |
| Background |
FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed with a high expression in intestine and prostaste. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. |
| Host |
NZ white rabbit |
| Purity |
Whole serum |
| Clonality |
Polyclonal |
| Isotype |
Polyclonal, whole serum |
| Applications |
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Specificity |
Specific for TRPM4. |
| Spcs X-react. |
Human. Other species not yet tested. |
| Format |
Lyophilised |
| Reconstitution |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage |
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Expiry Date |
12 months after reconstitution |
| Transportation |
This item will be shipped to you at ambient temperature in a lyophilised form. |
| References |
1. Xu X.-Z.S, et al. Proc. Natl. Acad. Sci. U.S.A. 98:10692-10697(2001).
2. Launay P, et al. Cell 109:397-407(2002).
3. Hofmann T, et al. Curr. Biol. 13:1153-1158(2003).
4. Ota T, et al. Nat. Genet. 36:40-45(2004).
5. Earley S, et al. Circ. Res. 95:922-929(2004).
6. Launay P, et al. Science 306:1374-1377(2004). |
| Limitation |
For research use only |
Primary Antibodies 
