A synthetic peptide from the c-terminal region of human CNG channel alpha-4 (CNG4, CNGA4) conjugated to an immunogenic carrier protein was used as the antigen.
Also known as
CNGA4, cGMP-gated cation channel alpha-4, CNG-4, CNG4, Cyclic nucleotide-gated channel alpha-4, Cyclic nucleotide-gated channel, photoreceptor, Cyclic nucleotide gated cation channel 3, Cone photoreceptor cGMP-gated channel subunit alpha, CNCG4, CNG 4
FUNCTION: Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Ota T, et al. Nat. Genet. 36:40-45(2004)
2. Taylor T.D, et al. Nature 440:497-500(2006)
3. Bradley J, et al. Nat. Neurosci. 7:705-710(2004)
4. Brady J.D, et al. Proc. Natl. Acad. Sci. U.S.A. 103:15635-15640(2006)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for CNGA4.
Human. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.