Rabbit antibody to C-terminal of human Telomerase reverse transcriptase (HEST2, TP2, TERT, EST2, TCS1, TRT): whole serum

$240USD

Code	OST00053W
ID Tag	Rb410-200308-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide as a part of C-terminal of human Telomerase reverse transcriptase (HEST2, TP2, TERT, EST2, TCS1, TRT) conjugated to an immunogenic carrier protein was used as the immunogen.
Conjugate	Unconjugated antibody
Accession	TERT_HUMAN
Also known as	Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT
Background	FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SUBUNIT: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1. SUBCELLULAR LOCATION: Nucleus. Telomere. DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Specificity	Specific for TERT.
Spcs X-react.	Human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Nakamura T.M, et al. Science 277:955-959(1997). 2. Meyerson M, et al. Cell 90:785-795(1997). 3. Wick M, et al. Gene 232:97-106(1999). 4. Hisatomi H, et al. Neoplasia 5:193-197(2003). 5. Tsakiri K.D, et al. Proc. Natl. Acad. Sci. U.S.A. 104:7552-7557(2007). 6. Matsubara Y, et al. Biochem. Biophys. Res. Commun. 348:669-672(2006). 7. Armanios M, et al. Proc. Natl. Acad. Sci. U.S.A. 102:15960-15964(2005). 8. Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). 9. Tao W.A, et al. Nat. Methods 2:591-598(2005). 10. Song H, et al. Biochem. Biophys. Res. Commun. 316:1116-1123(2004).
Limitation	For research use only

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Associated Products

Code	Product Name
OST00050W	Rabbit antibody to N-terminal of human Telomerase reverse transcriptase (HEST2, TP2, TERT, EST2, TCS1, TRT): whole serum
OST00051W	Rabbit antibody to internal region of human Telomerase reverse transcriptase (HEST2, TP2, TERT): whole serum
OST00052W	Rabbit antibody to internal part of human Telomerase reverse transcriptase (TERT): whole serum