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||A synthetic peptide from 2d cytoplasmic domain of human Connexin-46 (CX46, CXA3) conjugated to an immunogenic carrier protein was used as the antigen.
|Also known as
||CXA3, Gap junction alpha-3 protein, Connexin-46, Connexin 46, Connexin46, GJA3
||FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Tissue specificity: Low levels were detected in skin, heart, kidney, testis, ovary, intestine. Expression not detected in brain, sciatic nerve or liver.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
||NZ white rabbit
||Polyclonal, whole serum
||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
||Specific for Connexin-46.
||Human. Other species not yet tested.
||Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
||12 months after reconstitution
||This item will be shipped to you at ambient temperature in a lyophilised form.
||1. Mackay D, et al. Am. J. Hum. Genet. 64:1357-1364(1999)
2. Dunham A, et al. Nature 428:522-528(2004)
3. Rees M.I, et al. Hum. Genet. 106:206-209(2000)
4. Jiang H, et al. Mol. Vis. 9:579-583(2003)
5. Hansen L, et al. Mol. Vis. 12:1033-1039(2006)
||For research use only