Rabbit antibody to cFos (c-fos): whole serum

$240USD

Code	OSR00004W
ID Tag	Rb28-180407-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide as a part of human cFos protein conjugated to immunogenic carrier protein has been used as the immunogen. The peptide is homologous with the corresponding sequence derived from cFos protein in many other species including rat, mouse, hamster and cat.
Purity	Whole serum
Conjugate	Unconjugated antibody
Accession	cFOS_HUMAN cFOS_RAT cFOS_MOUSE cFOS_hamster cFos_cat
Also known as	Proto-oncogene protein cFOS, c-Fos
Background	FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB SUBCELLULAR LOCATION: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily SIMILARITY: Contains 1 bZIP domain
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal antibody
Isotype	Polyclonal, whole serum
Applications	IHC, WB. Use at a dilution of 1 : 400 to 1 : 8000. The optimal dilution should be determined by the end user.
Specificity	Appears to be specific for cFOS.
Spcs X-react.	Rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after purchase
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. van Straaten F, et al. Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983). 2. Hai T, et al. Genes Dev. 3:2083-2090(1989). 3. Heilig R, et al. Nature 421:601-607(2003). 4. Roux P, et al. Oncogene 6:2155-2160(1991). 5. Nakabeppu Y, et al. EMBO J. 8:3833-3841(1989). 6. Glover J.N, et al. Nature 373:257-261(1995). 7. Roux P, et al. Oncogene 6:2155-2160(1991). 8. Vasilescu J, et al. J. Proteome Res. 6:298-305(2007).
Limitation	For research use only

Rabbit antibody to cFos (c-fos): whole serum

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml (green), Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at 1 : 500 dilution and DAPI counterstained appearing in blue.

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat trigeminal using Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at a 1 : 500 dilution.

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat trigeminal using Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at a 1 : 500 dilution.

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml (green), Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at a 1 : 500 dilution and DAPI counterstained appearing in blue.

IF on rat olfactory bulb using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat olfactory bulb using Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at a 1 : 500 dilution.

IF on rat olfactory bulb using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml (green), Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at a 1 : 500 dilution and DAPI counterstained appearing in blue.

IF on rat olfactory bulb using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat olfactory bulb using Rabbit antibody to cFos (c-fos): whole serum (OSR00004W) at a 1 : 500 dilution.

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Associated Products

Code	Product Name
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OSC00007W	Sheep antibody to cFos (c-fos): whole serum
OSC00011G	Sheep antibody to cFos (c-fos): IgG