Nerve growth factor receptor (TNFR superfamily, member 16)
TNR16, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, Tnfrsf16, Ngfr, p75, LNGFR, RNNGFRR
FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long
term storage and refrigerated at 2-8°C for a shorter term. When
reconstituting, glycerol (1:1) may be added for an additional stability. Avoid
freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Sivilia S, et al. Histol. Histopathol. 23 (1), 1-10(2008).
2. Johnson D, et al. Cell 47, 545-54(1986).
3. Chandler, C. E, et al. J Biol Chem 259, 6882-6889(1984).
4. Yan, Q, et al. J Neurosci 8, 3481-3498(1988).
For research use only
WB, IHC, ELISA. A working concentration of 5-15 µg/ml is recommended. This antibody is suitable for use in paraformaldehyde fixed, alcohol fixed and paraffin-embedded sections. The optimal working solution should be determined by the end user.
Specific for rat p75NTR.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.