MC192 antibody, p75NTR antibody, low affinity NGF receptor antibody

Mouse monoclonal antibody to rat p75NTR (low affinity NGF receptor, MC192)

$240USD

Code	OSM00019A
ID Tag	MC192-131207-AP
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µg
Immunogen	Nerve growth factor receptor (TNFR superfamily, member 16)
Conjugate	Unconjugated antibody
Accession	LNGFR_RAT
Also known as	TNR16, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, Tnfrsf16, Ngfr, p75, LNGFR, RNNGFRR
Background	FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Host	Mouse
Purity	Affinity purified
Clonality	Monoclonal
Isotype	IgG1
Applications	WB, IHC, ELISA. A working concentration of 5-15 µg/ml is recommended. This antibody is suitable for use in paraformaldehyde fixed, alcohol fixed and paraffin-embedded sections. The optimal working solution should be determined by the end user.
Specificity	Specific for rat p75NTR.
Spcs X-react.	Rat
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Sivilia S, et al. Histol. Histopathol. 23 (1), 1-10(2008). 2. Johnson D, et al. Cell 47, 545-54(1986). 3. Chandler, C. E, et al. J Biol Chem 259, 6882-6889(1984). 4. Yan, Q, et al. J Neurosci 8, 3481-3498(1988). 5. Liepinsh E, et al. EMBO J. 16 (16), 4999-5005(1997). 6. Nemoto K, et al. Brain Res. 655 (1-2), 267-270(1994). 7. Sposato V, et al. Arch Ital Biol 145 (2), 87-97(2007).
Limitation	For research use only

Mouse monoclonal antibody to rat p75NTR (low affinity NGF receptor, MC192)

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml, Rabbit antibody to internal part of cFos (c-fos): whole serum (OSC00040W) at 1 : 500 dilution and DAPI counterstained.

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml (green), Rabbit antibody to internal part of cFos (c-fos): whole serum (OSC00040W) at 1 : 500 dilution and DAPI counterstained appearing in blue.

IF on rat olfactory bulb using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat olfactory bulb using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml (green), Rabbit antibody to internal part of cFos (c-fos): whole serum (OSC00040W) at 1 : 500 dilution and DAPI counterstained appearing in blue.

IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

IF on rat olfactory bulb using Mouse monoclonal antibody to rat p75NTR (OSM00019A) at a concentration of 10 µg/ml.

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Associated Products

Code	Product Name
OSM00018A	Mouse monoclonal antibody to p75NTR (ME20.4, low affinity NGF receptor)