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Code
OST00475W
$240USD    Buy Now 

ID Tag
Rb2843-090916-WS

Immunogen
A synthetic peptide from mouse TRPC4 conjugated to blue carrier protein was used as the antigen.
The location of the epitope is highlighted in green.

Accession

Also known
Short transient receptor potential channel 4, TrpC4, Trp4, Capacitative calcium entry channel 1, CCE1, Trrp4, Receptor-activated cation channel TRP4, Trp-related protein 4

Target
FUNCTION: Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
SUBUNIT: Isoform alpha but not isoform beta associates with inositol-1,4,5-triphosphate receptor (ITPR). Interacts with NHERF.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
- TISSUE SPECIFICITY: Abundantly expressed in brain (hippocampal CA1 pyramidal neurons, dentate gyrus granule cells, and cerebral cortical neurons, and in the septal nuclei and the mitral layer of olfactory bulb). Lower levels are detected in other tissues.
- TISSUE SPECIFICITY: Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Funayama M, et al. Brain Res. Mol. Brain Res. 43:259-266(1996).

Limitation
For research use only

Code
OST00475W
$240USD    Buy Now 

Unit size
100 l

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
Whole serum

Clonality
Polyclonal

Isotype
Polyclonal, whole serum

Applications
IHC, WB. A dilution of 1: 1000 is recommended. Recommended incubation time: 2 days at 4C. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for TRPC4.

Spcs X-react.
Mouse. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 100 l of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code
OST00475W
$240USD    Buy Now 


Rabbit antibody to TRPC4 WB on mouse tissue lysates. Blocking: 1% LFDM for 30 min at RT; primary antibody: dilution 1:1000 incubated 2 days at 4C. Click on eLAB BOOK tab to see the details.

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Rabbit antibody to TRPC4