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Code
OSL00012W
$240USD
ID Tag
Rb1359-140310-WS
Immunogen
A synthetic peptide from c-terminal region of human Lingo1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many other species.
Accession
Also known
LIGO1, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat and immunoglobilin domain-containing protein 1, Leucine-rich repeat neuronal protein 6A, Leucine-rich repeat neuronal protein 1, LERN1, LRRN6A
Target
Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Subcellular location: Cell membrane; Single-pass type I membrane protein
Tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
Subcellular location: Cell membrane; Single-pass type I membrane protein
Tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Carim-Todd L, et al. Eur. J. Neurosci. 18:3167-3182(2003)
2. Mosyak L, et al. J. Biol. Chem. 281:36378-36390(2006)
2. Mosyak L, et al. J. Biol. Chem. 281:36378-36390(2006)
Limitation
For research use only
Code
OSL00012W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 3000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for Lingo1.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
- Click to see the eLab Book
Code
OSL00012W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
Code
OSL00012W
$240USD
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WB on brain lysates. Blocking with 1% LFDM for 30 min at RT; Primary antibody used at 1:3000 dilution incubated overnight at 4C. Click on eLAB BOOK tab to see the details. |
⚬ Products
Rabbit antibody to Lingo1
